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Mouse Anti-AFAP1L2 Monoclonal Antibody (V2-5179) (CBMAB-0927-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-5179
Antibody Isotype
IgG2a, κ
Application
IP, IF, WB

Basic Information

Immunogen
Recombinant AFAP-1L2 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Actin Filament Associated Protein 1 Like 2
Introduction
Actin filament associated protein 1 like 2 (AFAP1L2) is a cytosolic adaptor protein and signal transduction mediator which is highly expressed in the thyroid and spleen. AFAP1L2 regulates cell proliferation, cell survival, cell motility and gene expression. XB130 is highly similar to AFAP and is a substrate and regulator of multiple tyrosine kinase-mediated signaling.
Entrez Gene ID
Human84632
Monkey698518
UniProt ID
HumanQ8N4X5
MonkeyA0A2K6UTU6
Alternative Names
XB130; KIAA1914; CTB-1144G6.4
Function
May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
Biological Process
Inflammatory response
Positive regulation of epidermal growth factor receptor signaling pathway
Positive regulation of interleukin-8 production
Positive regulation of transcription, DNA-templated
Regulation of interleukin-6 production
Regulation of mitotic cell cycle
Cellular Location
Cytoplasm
PTM
Tyrosine phosphorylated (by SRC).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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