Rabbit Anti-ADIPOQ Recombinant Antibody (V2-179923) (CBMAB-A1307-YC)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

V2-179923

Antibody Isotype

IgG

Application

IHC-P, WB

Basic Information

Immunogen

Recombinant protein corresponding to amino acids 57=244 of human adiponectin

Host Species

Rabbit

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1-2 μg/ml
IHC-P	1:100
IF(ICC)	5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, 0.09% sodium azide

Buffer

PBS

Preservative

0.09% sodium azide

Concentration

0.5 mg/ml

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Adiponectin, C1Q And Collagen Domain Containing

Introduction

ADIPOQ is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in thi

Entrez Gene ID

Human	9370
Mouse	11450

UniProt ID

Human	Q15848
Mouse	Q60994

Alternative Names

Adiponectin, C1Q And Collagen Domain Containing; Adipose Most Abundant Gene Transcript 1 Protein; Adipocyte Complement-Related 30 KDa Protein; 30 KDa Adipocyte Complement-Related Protein; ACRP30; APM-1; GBP28; ACDC; APM1; Adipocyte, C1q And Collagen Domai

Function

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity).

Biological Process

Adiponectin-activated signaling pathway
Fatty acid oxidation
Glucose homeostasis
Hormone-mediated signaling pathway
Leptin-mediated signaling pathway
Negative regulation of cell growth
Negative regulation of epithelial cell migration
Negative regulation of epithelial to mesenchymal transition
Negative regulation of NIK/NF-kappaB signaling
Negative regulation of receptor signaling pathway via JAK-STAT
Positive regulation of cold-induced thermogenesis
Positive regulation of insulin receptor signaling pathway
Positive regulation of receptor signaling pathway via JAK-STAT
Regulation of fatty acid biosynthetic process
Regulation of glucose metabolic process
Regulation of lipid metabolic process

Cellular Location

Cell membrane. Localized to the cell membrane and intracellular organelles.

Topology

Cytoplasmic: 1-136 aa
Helical: 137-157 aa
Extracellular: 158-170 aa
Helical: 171-191 aa
Cytoplasmic: 192-203 aa
Helical: 204-224 aa
Extracellular: 225-234 aa
Helical: 235-255 aa
Cytoplasmic: 256-264 aa
Helical: 265-285 aa
Extracellular: 286-298 aa
Helical: 299-319 aa
Cytoplasmic: 320-337 aa
Helical: 338-358 aa
Extracellular: 359-375 aa

More Infomation

References

Mamoor, S. (2021). Differential expression of adiponectin, C1Q and collagen domain containing in cancers of the breast.

Wang, Q., Ren, D., Bi, Y., Yuan, R., Li, D., Wang, J., ... & Liu, B. (2020). Association and functional study between ADIPOQ and metabolic syndrome in elderly Chinese Han population. Aging (Albany NY), 12(24), 25819.

Coutinho, C. A. A. C., Marson, F. A. L., Ribeiro, J. D., & Bertuzzo, C. S. (2020). A negative screening of rare genetic variants in the ADIPOQ and STATH genes in cystic fibrosis. Pulmonology, 26(3), 138-144.

Chung, S. J., Nagaraju, G. P., Nagalingam, A., Muniraj, N., Kuppusamy, P., Walker, A., ... & Sharma, D. (2017). ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy, 13(8), 1386-1403.

Ye, L., Wang, G., Tang, Y., & Bai, J. (2017). A population-specific correlation between ADIPOQ rs2241766 and rs 1501299 and colorectal cancer risk: a meta-analysis for debate. International journal of clinical oncology, 22(2), 307-315.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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