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Mouse Anti-ACVR2A Recombinant Antibody (V2-12517) (CBMAB-1007-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-12517
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to aa. 214-513 of human ACVR2A (NP_001607) produced in E. coli
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:200-1:500
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ACTIVIN A RECEPTOR TYPE 2A
Introduction
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. On ligand binding, is forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. This is a receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.
Entrez Gene ID
92
UniProt ID
P27037
Alternative Names
ACVR2; ACTRII
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Biological Process
Activin receptor signaling pathway
Anterior/posterior pattern specification
BMP signaling pathway
Cellular response to BMP stimulus
Cellular response to growth factor stimulus
Determination of left/right symmetry
Embryonic skeletal system development
Gastrulation with mouth forming second
Mesoderm development
Negative regulation of BMP signaling pathway
Penile erection
Positive regulation of activin receptor signaling pathway
Positive regulation of BMP signaling pathway
Positive regulation of bone mineralization
Positive regulation of erythrocyte differentiation
Positive regulation of osteoblast differentiation
Positive regulation of pathway-restricted SMAD protein phosphorylation
Positive regulation of protein phosphorylation
Positive regulation of transcription by RNA polymerase II
Protein phosphorylation
Regulation of nitric-oxide synthase activity
Sertoli cell proliferation
Spermatogenesis
Sperm ejaculation
Transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Location
Membrane
Topology
Extracellular: 20-135 aa
Helical: 136-161 aa
Cytoplasmic: 162-513 aa
More Infomation

Yuza, K., Nagahashi, M., Ichikawa, H., Hanyu, T., Nakajima, M., Shimada, Y., ... & Wakai, T. (2021). Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-11.

Monsivais, D., Nagashima, T., Prunskaite-Hyyryläinen, R., Nozawa, K., Shimada, K., Tang, S., ... & Matzuk, M. M. (2021). Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. Nature communications, 12(1), 1-17.

Zhang, B., Liang, T., & Ru, G. (2021). Letter to the Editor: Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-2.

Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brûlé, E., ... & Bernard, D. J. (2020). Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B. Endocrinology, 161(7).

Bhattacharya, T. K., Shukla, R., Chatterjee, R. N., & Bhanja, S. K. (2019). Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Scientific reports, 9(1), 1-13.

Zhuo, C., Hu, D., Lin, X., Chen, Y., Zheng, X., & Yang, C. (2018). Down expression of activin A receptor type 2A in relation to metastatic potential and prognosis of patients with colon cancer.

Zhang, H., Ju, B., Nie, Y., Song, B., Xu, Y., & Gao, P. (2018). Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells. International journal of molecular medicine, 42(1), 279-289.

Zhuo, C., Hu, D., Li, J., Yu, H., Lin, X., Chen, Y., ... & Yang, C. (2018). Downregulation of activin a receptor type 2A is associated with metastatic potential and poor prognosis of colon cancer. Journal of Cancer, 9(19), 3626.

Goh, B. C., Singhal, V., Herrera, A. J., Tomlinson, R. E., Kim, S., Faugere, M. C., ... & DiGirolamo, D. J. (2017). Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. Journal of Biological Chemistry, 292(33), 13809-13822.

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For research use only. Not intended for any clinical use.

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