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Mouse Anti-ACVR2A Recombinant Antibody (V2-179689) (CBMAB-A1045-YC)


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Published Data
Mouse Anti-ACVR2A Recombinant Antibody (149/1) (CBMAB-A1045-YC) in WB
Western blot analysis. PC12 cells were treated with OGD for 6 h or different concentrations of ActA for 24 h combined with OGD for 6 h. ActRIIA, Smad3 and Smad4 expression levels were determined using western blots. The results shown are representative of three independent experiments. NIH imaging indicated that the protein signal densities increased in the groups treated with ActA combined with OGD for 6 h compared with OGD for 6 h-treated groups. ...View More
He, J. T., Mang, J., Mei, C. L., Yang, L., Wang, J. Q., Xing, Y., ... & Xu, Z. X. (2011). Neuroprotective effects of exogenous activin A on oxygen-glucose deprivation in PC12 cells. Molecules, 17(1), 315-327.

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
V2-179689
Antibody Isotype
IgG1
Application
IP, WB

Basic Information

Immunogen
Recombinant intracellular kinase domain of the human type 2 activin receptor
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate).

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS
Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ACTIVIN A RECEPTOR TYPE 2A
Introduction
ACVR2A is a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor
Entrez Gene ID
Human92
Rat29263
UniProt ID
HumanP27037
RatP38444
Alternative Names
Activin A Receptor Type 2A; Activin A Receptor, Type IIA; EC 2.7.11.30; ACVR2; Activin A Receptor, Type II; Activin Receptor Type IIA;
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Biological Process
Activin receptor signaling pathway
Anterior/posterior pattern specification
BMP signaling pathway
Cellular response to BMP stimulus
Cellular response to growth factor stimulus
Determination of left/right symmetry
Embryonic skeletal system development
Gastrulation with mouth forming second
Mesoderm development
Negative regulation of BMP signaling pathway
Penile erection
Positive regulation of activin receptor signaling pathway
Positive regulation of BMP signaling pathway
Positive regulation of bone mineralization
Positive regulation of erythrocyte differentiation
Positive regulation of osteoblast differentiation
Positive regulation of pathway-restricted SMAD protein phosphorylation
Positive regulation of protein phosphorylation
Positive regulation of transcription by RNA polymerase II
Protein phosphorylation
Regulation of nitric-oxide synthase activity
Sertoli cell proliferation
Spermatogenesis
Sperm ejaculation
Transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Location
Membrane
Topology
Extracellular: 20-135 aa
Helical: 136-161 aa
Cytoplasmic: 162-513 aa
More Infomation

Yuza, K., Nagahashi, M., Ichikawa, H., Hanyu, T., Nakajima, M., Shimada, Y., ... & Wakai, T. (2021). Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-11.

Monsivais, D., Nagashima, T., Prunskaite-Hyyryläinen, R., Nozawa, K., Shimada, K., Tang, S., ... & Matzuk, M. M. (2021). Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. Nature communications, 12(1), 1-17.

Zhang, B., Liang, T., & Ru, G. (2021). Letter to the Editor: Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-2.

Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brûlé, E., ... & Bernard, D. J. (2020). Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B. Endocrinology, 161(7).

Bhattacharya, T. K., Shukla, R., Chatterjee, R. N., & Bhanja, S. K. (2019). Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Scientific reports, 9(1), 1-13.

Zhuo, C., Hu, D., Lin, X., Chen, Y., Zheng, X., & Yang, C. (2018). Down expression of activin A receptor type 2A in relation to metastatic potential and prognosis of patients with colon cancer.

Zhang, H., Ju, B., Nie, Y., Song, B., Xu, Y., & Gao, P. (2018). Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells. International journal of molecular medicine, 42(1), 279-289.

Zhuo, C., Hu, D., Li, J., Yu, H., Lin, X., Chen, Y., ... & Yang, C. (2018). Downregulation of activin a receptor type 2A is associated with metastatic potential and poor prognosis of colon cancer. Journal of Cancer, 9(19), 3626.

Goh, B. C., Singhal, V., Herrera, A. J., Tomlinson, R. E., Kim, S., Faugere, M. C., ... & DiGirolamo, D. J. (2017). Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. Journal of Biological Chemistry, 292(33), 13809-13822.

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For research use only. Not intended for any clinical use.

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