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Rabbit Anti-ACTR2 Recombinant Antibody (V2-179657) (CBMAB-A1009-YC)


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Published Data
Rabbit Anti-ACTR2 Recombinant Antibody (D85D5) (CBMAB-A1009-YC) in WB
Expression of actin related protein 2, ARP2 in normal and CRC cells. Cells were grown and treated with atypical PKC inhibitors for three consecutive days. Equal amount of cell lysate was subjected to western blot analysis. Expression of ARP2, an actin nucleating protein in healthy and cancerous cells. α-Tubulin was used as a loading control. ...View More
Islam, S. A., Patel, R., Bommareddy, R. R., Khalid, K. M., & Acevedo-Duncan, M. (2019). The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells. Cell Adhesion & Migration, 13(1), 106-120.
Rabbit Anti-ACTR2 Recombinant Antibody (D85D5) (CBMAB-A1009-YC) in WB
Young and aging AMϕ were treated with or without E. coli (MOI=4) for 30 min, the total Arp2 and its phosphorylated form were measured by Western Blot. The graph depicts mean ± SEM of p-Arp2/t-Arp2 intensity fold induction, n=3. Statistical analysis using two-way ANOVA, Interaction p = 0.0003. Tukey's multiple comparisons test shows that Young/Control vs. Young/E. coli, p = 0.0006, Young/E. coli vs. Age/E. coli, p = 0.0007. ...View More
Li, Z., Jiao, Y., Fan, E. K., Scott, M. J., Li, Y., Li, S., ... & Fan, J. (2017). Aging-impaired filamentous actin polymerization signaling reduces alveolar macrophage phagocytosis of bacteria. The Journal of Immunology, 199(9), 3176-3186.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle
Clone
V2-179657
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the carboxy terminus of human ARP2 protein.
Host Species
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Actinin Alpha 2
Introduction
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamel
Entrez Gene ID
Human10097
Mouse66713
Rat289820
Monkey697080
Cattle538486
UniProt ID
HumanP61160
MouseP61161
RatQ5M7U6
MonkeyA0A0D9RQK6
CattleA7MB62
Alternative Names
ARP2
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Biological Process
Arp2/3 complex-mediated actin nucleation
Associative learning
Asymmetric cell division
Cellular response to interferon-gamma
Cellular response to trichostatin A
Cilium assembly
Cytosolic transport
Ephrin receptor signaling pathway
Establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
Meiotic chromosome movement towards spindle pole
Meiotic cytokinesis
Membrane organization
Neutrophil degranulation
Positive regulation of dendritic spine morphogenesis
Positive regulation of double-strand break repair via homologous recombination
Positive regulation of lamellipodium assembly
Positive regulation of transcription by RNA polymerase II
Response to ethanol
Response to immobilization stress
Spindle localization
Cellular Location
Nucleus; Cytoskeleton; Cell projection
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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