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Mouse Anti-ACTR2 Recombinant Antibody (V2-179656) (CBMAB-A1008-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179656
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
ACTR2 (AAH14546.1, 1 a.a. ~ 394 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC-P3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Actinin Alpha 2
Introduction
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamel
Entrez Gene ID
10097
UniProt ID
P61160
Alternative Names
ARP2 Actin Related Protein 2 Homolog; Actin-Like Protein 2; ARP2; ARP2 (Actin-Related Protein 2, Yeast) Homolog; ARP2 Actin-Related Protein 2 Homolog (Yeast); Actin-Related Protein 2;
Function
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Biological Process
Arp2/3 complex-mediated actin nucleation
Associative learning
Asymmetric cell division
Cellular response to interferon-gamma
Cellular response to trichostatin A
Cilium assembly
Cytosolic transport
Ephrin receptor signaling pathway
Establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
Meiotic chromosome movement towards spindle pole
Meiotic cytokinesis
Membrane organization
Neutrophil degranulation
Positive regulation of dendritic spine morphogenesis
Positive regulation of double-strand break repair via homologous recombination
Positive regulation of lamellipodium assembly
Positive regulation of transcription by RNA polymerase II
Response to ethanol
Response to immobilization stress
Spindle localization
Cellular Location
Nucleus; Cytoskeleton; Cell projection
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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