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Mouse Anti-ACSL5 Recombinant Antibody (V2-179446) (CBMAB-A0753-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179446
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to Human ACSL5
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1 µg/ml
IHC-P1:50-1:200
IHC1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2, 40% glycerol, 0.02% sodium azide
Buffer
PBS, pH7.2, 40% Glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Acyl-CoA Synthetase Long Chain Family Member 5
Introduction
ACSL5 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA
Entrez Gene ID
51703
UniProt ID
Q9ULC5
Alternative Names
Acyl-CoA Synthetase Long Chain Family Member 5; Fatty-Acid-Coenzyme A Ligase, Long-Chain 5; Long-Chain Acyl-CoA Synthetase 5; Long-Chain Fatty Acid Coenzyme A Ligase 5; FACL5 For Fatty Acid Coenzyme A Ligase 5; EC 6.2.1.3; LACS 5;
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Biological Process
Lipid biosynthetic process
Long-chain fatty acid metabolic process
Long-chain fatty-acyl-CoA biosynthetic process
Positive regulation of long-chain fatty acid import across plasma membrane
Regulation of extrinsic apoptotic signaling pathway
Cellular Location
Cell membrane; Mitochondrion; Mitochondrion outer membrane; Endoplasmic reticulum; Endoplasmic reticulum membrane
Topology
Helical: 12-32 aa
Cytoplasmic: 33-683 aa
More Infomation

Zhang, L., Lv, J., Chen, C., & Wang, X. (2021). Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism. Cell biology and toxicology, 37(1), 15-34.

Al‐Thihli, K., Afting, C., Al‐Hashmi, N., Mohammed, M., Sliwinski, S., Al Shibli, N., ... & Al‐Maawali, A. (2021). Deficiency of acyl‐CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset. Clinical Genetics, 99(3), 376-383.

Gharib, E., Nasri Nasrabadi, P., & Reza Zali, M. (2020). miR‐497‐5p mediates starvation‐induced death in colon cancer cells by targeting acyl‐CoA synthetase‐5 and modulation of lipid metabolism. Journal of cellular physiology, 235(7-8), 5570-5589.

O’Brien, M. J., Beijerink, N. J., Sansom, M., Thornton, S. W., Chew, T., & Wade, C. M. (2020). A large deletion on CFA28 omitting ACSL5 gene is associated with intestinal lipid malabsorption in the Australian Kelpie dog breed. Scientific reports, 10(1), 1-10.

Yu, X., Fang, X., Xiao, H., Zhao, Z., Maak, S., Wang, M., & Yang, R. (2019). The effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytes. Archives animal breeding, 62(1), 257-264.

Kwak, H. B., Woodlief, T. L., Green, T. D., Cox, J. H., Hickner, R. C., Neufer, P. D., & Cortright, R. N. (2019). Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. International journal of environmental research and public health, 16(7), 1157.

Rossi Sebastiano, M., & Konstantinidou, G. (2019). Targeting long chain acyl-coa synthetases for cancer therapy. International journal of molecular sciences, 20(15), 3624.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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