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ACSL5 Matched Antibody Pair (007) (APMAB-007LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-ACSL5 monoclonal antibody, 100 ug
Detection Antibody
Anti-ACSL5 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
Acyl-CoA Synthetase Long Chain Family Member 5; Fatty-Acid-Coenzyme A Ligase, Long-Chain 5; Long-Chain Acyl-CoA Synthetase 5; Long-Chain Fatty Acid Coenzyme A Ligase 5; FACL5 For Fatty Acid Coenzyme A Ligase 5; EC 6.2.1.3; LACS 5;
Entrez Gene ID
51703
UniProt ID
Q9ULC5
More Infomation

Zhang, L., Lv, J., Chen, C., & Wang, X. (2021). Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism. Cell biology and toxicology, 37(1), 15-34.

Al‐Thihli, K., Afting, C., Al‐Hashmi, N., Mohammed, M., Sliwinski, S., Al Shibli, N., ... & Al‐Maawali, A. (2021). Deficiency of acyl‐CoA synthetase 5 is associated with a severe and treatable failure to thrive of neonatal onset. Clinical Genetics, 99(3), 376-383.

Gharib, E., Nasri Nasrabadi, P., & Reza Zali, M. (2020). miR‐497‐5p mediates starvation‐induced death in colon cancer cells by targeting acyl‐CoA synthetase‐5 and modulation of lipid metabolism. Journal of cellular physiology, 235(7-8), 5570-5589.

O’Brien, M. J., Beijerink, N. J., Sansom, M., Thornton, S. W., Chew, T., & Wade, C. M. (2020). A large deletion on CFA28 omitting ACSL5 gene is associated with intestinal lipid malabsorption in the Australian Kelpie dog breed. Scientific reports, 10(1), 1-10.

Yu, X., Fang, X., Xiao, H., Zhao, Z., Maak, S., Wang, M., & Yang, R. (2019). The effect of acyl-CoA synthetase long-chain family member 5 on triglyceride synthesis in bovine preadipocytes. Archives animal breeding, 62(1), 257-264.

Kwak, H. B., Woodlief, T. L., Green, T. D., Cox, J. H., Hickner, R. C., Neufer, P. D., & Cortright, R. N. (2019). Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. International journal of environmental research and public health, 16(7), 1157.

Rossi Sebastiano, M., & Konstantinidou, G. (2019). Targeting long chain acyl-coa synthetases for cancer therapy. International journal of molecular sciences, 20(15), 3624.

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For research use only. Not intended for any clinical use.

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