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TCF7 Matched Antibody Pair (1191) (APMAB-1191LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-TCF7 polyclonal antibody, 100 ug
Detection Antibody
Anti-TCF7 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
Alternative Names
Transcription Factor 7; Transcription Factor 7 (T-Cell Specific, HMG-Box); T-Cell-Specific Transcription Factor 1; T-Cell-Factor-7; TCF-1; T-Cell Factor 1; TCF-7; TCF1;
Entrez Gene ID
6932
UniProt ID
P36402
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For research use only. Not intended for any clinical use.

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