ZNF410

Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.

ZNF410

Transcription factor that binds to the sequence motif 5'-CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33859416, PubMed:33301730).
Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33859416, PubMed:33301730).
May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286).
May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215).
However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33859416, PubMed:33301730).

Biological Process negative regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Nucleus
Chromosome
Note: Directly binds to the sequence motif 5'-CATCCCATAATA-3'.

Sumoylated (PubMed:12370286).
Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation (PubMed:12370286).
O-glycosylated (PubMed:30078215).
O-GlcNAcylation may occur in response to increasing glucose levels and affect transcription factor activity (PubMed:30078215).