ZNF397

This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

Zinc Finger Protein 397

Isoform 3 acts as a DNA-dependent transcriptional repressor.

Biological Process negative regulation of DNA-templated transcription Source:UniProtKB
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication

Isoform 1
Nucleus
Isoform 3
Nucleus
Cytoplasm