ZFAND2B

ZFAND2B (Zinc Finger AN1-Type Containing 2B) is a Protein Coding gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. An important paralog of this gene is ZFAND2A.

Zinc Finger AN1-Type Containing 2B

Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (By similarity).
By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).

Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process protein targeting to ER Source:UniProtKB1 Publication
Biological Process regulation of insulin-like growth factor receptor signaling pathway Source:UniProtKB
Biological Process SRP-dependent cotranslational protein targeting to membrane, translocation Source:MGI1 Publication

Endoplasmic reticulum membrane

Phosphorylated by MAPK14. Phosphorylation has no effect on association with the proteasome complex.