YES1

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

YES Proto-Oncogene 1, Src Family Tyrosine Kinase

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Biological Process cell differentiation Source:GO_Central1 Publication
Biological Process cellular response to platelet-derived growth factor stimulus Source:Ensembl
Biological Process cellular response to retinoic acid Source:Ensembl
Biological Process cellular response to transforming growth factor beta stimulus Source:Ensembl
Biological Process ephrin receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process leukocyte migration Source:Reactome
Biological Process negative regulation of inflammatory response to antigenic stimulus Source:Reactome
Biological Process positive regulation of peptidyl-tyrosine phosphorylation Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:Ensembl
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process regulation of glucose transmembrane transport Source:Ensembl
Biological Process regulation of vascular permeability Source:BHF-UCL1 Publication
Biological Process T cell costimulation Source:Reactome
Biological Process transmembrane receptor protein tyrosine kinase signaling pathway Source:GO_Central1 Publication

Cell membrane
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytosol
Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.

Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.
Palmitoylation at Cys-3 promotes membrane localization.