WNT5A

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Wnt Family Member 5B

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity).
Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754).
Mediates motility of melanoma cells (PubMed:17426020).
Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity).

Biological Process activation of GTPase activity Source:Ensembl
Biological Process activation of protein kinase B activity Source:BHF-UCL1 Publication
Biological Process anterior/posterior axis specification, embryo Source:Ensembl
Biological Process atrial septum development Source:Ensembl
Biological Process axon extension involved in axon guidance Source:Ensembl
Biological Process axon guidance Source:UniProtKB
Biological Process BMP signaling pathway Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:GO_Central1 Publication
Biological Process cartilage development Source:UniProtKB-KW
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cellular response to calcium ion Source:UniProtKB1 Publication
Biological Process cellular response to lipopolysaccharide Source:UniProtKB1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process cellular response to transforming growth factor beta stimulus Source:UniProtKB1 Publication
Biological Process cellular response to type II interferon Source:UniProtKB1 Publication
Biological Process cervix development Source:Ensembl
Biological Process chemoattraction of serotonergic neuron axon Source:Ensembl
Biological Process chemorepulsion of dopaminergic neuron axon Source:Ensembl
Biological Process cochlea morphogenesis Source:Ensembl
Biological Process convergent extension involved in axis elongation Source:Ensembl
Biological Process convergent extension involved in organogenesis Source:Ensembl
Biological Process embryonic digit morphogenesis Source:Ensembl
Biological Process embryonic skeletal system development Source:BHF-UCL1 Publication
Biological Process epithelial cell migration Source:Ensembl
Biological Process epithelial cell proliferation involved in mammary gland duct elongation Source:Ensembl
Biological Process epithelial to mesenchymal transition Source:UniProtKB1 Publication
Biological Process establishment of epithelial cell apical/basal polarity Source:Ensembl
Biological Process establishment of planar polarity Source:Ensembl
Biological Process excitatory synapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process face development Source:BHF-UCL1 Publication
Biological Process fibroblast growth factor receptor signaling pathway Source:Ensembl
Biological Process genitalia development Source:BHF-UCL1 Publication
Biological Process heart looping Source:Ensembl
Biological Process hematopoietic stem cell proliferation Source:BHF-UCL1 Publication
Biological Process hindgut morphogenesis Source:Ensembl
Biological Process hypophysis morphogenesis Source:Ensembl
Biological Process inhibitory synapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process JNK cascade Source:Ensembl
Biological Process keratinocyte differentiation Source:BHF-UCL1 Publication
Biological Process kidney development Source:Ensembl
Biological Process lateral sprouting involved in mammary gland duct morphogenesis Source:Ensembl
Biological Process lens development in camera-type eye Source:BHF-UCLBy Similarity
Biological Process lung development Source:Ensembl
Biological Process male gonad development Source:UniProtKB1 Publication
Biological Process mammary gland branching involved in thelarche Source:Ensembl
Biological Process meiotic nuclear division Source:Ensembl
Biological Process melanocyte proliferation Source:Ensembl
Biological Process mesenchymal cell proliferation Source:Ensembl
Biological Process mesenchymal-epithelial cell signaling Source:Ensembl
Biological Process mesodermal to mesenchymal transition involved in gastrulation Source:Ensembl
Biological Process midgut development Source:Ensembl
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of axon extension involved in axon guidance Source:Ensembl
Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of canonical Wnt signaling pathway Source:MGI2 Publications
Biological Process negative regulation of cell proliferation in midbrain Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process negative regulation of epithelial cell proliferation Source:Ensembl
Biological Process negative regulation of fat cell differentiation Source:BHF-UCL1 Publication
Biological Process negative regulation of fibroblast growth factor receptor signaling pathway Source:Ensembl
Biological Process negative regulation of melanin biosynthetic process Source:Ensembl
Biological Process negative regulation of mesenchymal cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of prostatic bud formation Source:Ensembl
Biological Process negative regulation of synapse assembly Source:Ensembl
Biological Process neuron differentiation Source:UniProtKB
Biological Process non-canonical Wnt signaling pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process non-canonical Wnt signaling pathway via JNK cascade Source:Ensembl
Biological Process notochord morphogenesis Source:Ensembl
Biological Process olfactory bulb interneuron development Source:UniProtKB
Biological Process optic cup formation involved in camera-type eye development Source:BHF-UCLBy Similarity
Biological Process paraxial mesoderm formation Source:Ensembl
Biological Process planar cell polarity pathway involved in axis elongation Source:Ensembl
Biological Process planar cell polarity pathway involved in axon guidance Source:Ensembl
Biological Process planar cell polarity pathway involved in cardiac muscle tissue morphogenesis Source:Ensembl
Biological Process planar cell polarity pathway involved in cardiac right atrium morphogenesis Source:Ensembl
Biological Process planar cell polarity pathway involved in gastrula mediolateral intercalation Source:Ensembl
Biological Process planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process planar cell polarity pathway involved in neural tube closure Source:Ensembl
Biological Process planar cell polarity pathway involved in outflow tract morphogenesis Source:Ensembl
Biological Process planar cell polarity pathway involved in pericardium morphogenesis Source:Ensembl
Biological Process planar cell polarity pathway involved in ventricular septum morphogenesis Source:Ensembl
Biological Process positive regulation of angiogenesis Source:UniProtKB1 Publication
Biological Process positive regulation of cartilage development Source:Ensembl
Biological Process positive regulation of cell-cell adhesion mediated by cadherin Source:Ensembl
Biological Process positive regulation of chemokine production Source:UniProtKB1 Publication
Biological Process positive regulation of cytokine production involved in immune response Source:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of endocytosis Source:Ensembl
Biological Process positive regulation of endothelial cell migration Source:UniProtKB2 Publications
Biological Process positive regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of fibroblast proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of gene expression Source:ARUK-UCL
Biological Process positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of hematopoietic stem cell proliferation Source:Ensembl
Biological Process positive regulation of inflammatory response Source:BHF-UCL1 Publication
Biological Process positive regulation of interleukin-1 beta production Source:BHF-UCL1 Publication
Biological Process positive regulation of interleukin-6 production Source:BHF-UCL1 Publication
Biological Process positive regulation of interleukin-8 production Source:Ensembl
Biological Process positive regulation of JNK cascade Source:Ensembl
Biological Process positive regulation of JUN kinase activity Source:BHF-UCL1 Publication
Biological Process positive regulation of macrophage activation Source:BHF-UCL1 Publication
Biological Process positive regulation of macrophage cytokine production Source:UniProtKB1 Publication
Biological Process positive regulation of meiotic nuclear division Source:Ensembl
Biological Process positive regulation of mesenchymal cell proliferation Source:Ensembl
Biological Process positive regulation of neuron death Source:ARUK-UCL
Biological Process positive regulation of neuron projection arborization Source:ARUK-UCL
Biological Process positive regulation of neuron projection development Source:UniProtKB
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of non-canonical Wnt signaling pathway Source:Ensembl
Biological Process positive regulation of ossification Source:BHF-UCL1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylation Source:Ensembl
Biological Process positive regulation of peptidyl-threonine phosphorylation Source:Ensembl
Biological Process positive regulation of protein binding Source:Ensembl
Biological Process positive regulation of protein catabolic process Source:MGI2 Publications
Biological Process positive regulation of protein kinase C activity Source:CACAO1 Publication
Biological Process positive regulation of protein kinase C signaling Source:UniProtKB1 Publication
Biological Process positive regulation of protein localization to synapse Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of response to cytokine stimulus Source:UniProtKB1 Publication
Biological Process positive regulation of T cell chemotaxis Source:UniProtKB1 Publication
Biological Process positive regulation of thymocyte apoptotic process Source:Ensembl
Biological Process positive regulation of timing of anagen Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:BHF-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor production Source:ARUK-UCL
Biological Process positive regulation of type I interferon-mediated signaling pathway Source:BHF-UCL1 Publication
Biological Process positive regulation of type II interferon production Source:Ensembl
Biological Process post-anal tail morphogenesis Source:Ensembl
Biological Process postsynapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process postsynaptic modulation of chemical synaptic transmission Source:Ensembl
Biological Process presynapse assembly Source:ParkinsonsUK-UCL1 Publication
Biological Process primary heart field specification Source:Ensembl
Biological Process primitive streak formation Source:Ensembl
Biological Process protein localization Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:Ensembl
Biological Process regulation of branching involved in mammary gland duct morphogenesis Source:Ensembl
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:ARUK-UCL
Biological Process regulation of inflammatory response Source:ARUK-UCL1 Publication
Biological Process regulation of postsynapse organization Source:SynGO2 Publications
Biological Process regulation of postsynaptic cytosolic calcium ion concentration Source:SynGO2 Publications
Biological Process regulation of synapse organization Source:SynGO2 Publications
Biological Process response to organic substance Source:UniProtKB1 Publication
Biological Process secondary heart field specification Source:Ensembl
Biological Process secondary palate development Source:BHF-UCL1 Publication
Biological Process somitogenesis Source:Ensembl
Biological Process thymocyte apoptotic process Source:Ensembl
Biological Process type B pancreatic cell development Source:Ensembl
Biological Process urinary bladder development Source:Ensembl
Biological Process uterus development Source:Ensembl
Biological Process vagina development Source:Ensembl
Biological Process Wnt signaling pathway Source:BHF-UCL1 Publication
Biological Process Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process Wnt signaling pathway, calcium modulating pathway Source:UniProtKB1 Publication
Biological Process Wnt signaling pathway, planar cell polarity pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process wound healing Source:UniProtKB1 Publication

Secreted, extracellular space, extracellular matrix
Secreted

Robinow syndrome, autosomal dominant 1 (DRS1):
A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases.

Glycosylation is necessary for secretion but not for activity.
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.