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WNT3

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Full Name
Wnt family member 3
Function
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720).
Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity).
Required for normal embryonic development, and especially for limb development (PubMed:14872406).
Biological Process
Biological Process anterior/posterior axis specification Source:Ensembl
Biological Process axon guidance Source:Ensembl
Biological Process canonical Wnt signaling pathway Source:UniProtKB1 Publication
Biological Process canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source:BHF-UCL1 Publication
Biological Process canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source:ParkinsonsUK-UCL1 Publication
Biological Process canonical Wnt signaling pathway involved in osteoblast differentiation Source:BHF-UCL1 Publication
Biological Process canonical Wnt signaling pathway involved in stem cell proliferation Source:ParkinsonsUK-UCL1 Publication
Biological Process cell fate commitment Source:GO_Central1 Publication
Biological Process cell morphogenesis Source:BHF-UCL1 Publication
Biological Process cellular response to retinoic acid Source:UniProtKB
Biological Process dorsal/ventral axis specification Source:Ensembl
Biological Process embryonic forelimb morphogenesis Source:Ensembl
Biological Process embryonic hindlimb morphogenesis Source:Ensembl
Biological Process gamete generation Source:Ensembl
Biological Process gene expression Source:Ensembl
Biological Process head morphogenesis Source:Ensembl
Biological Process limb bud formation Source:BHF-UCL1 Publication
Biological Process mammary gland epithelium development Source:UniProtKB1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process negative regulation of axon extension involved in axon guidance Source:Ensembl
Biological Process neuron differentiation Source:UniProtKB
Biological Process positive regulation of collateral sprouting in absence of injury Source:Ensembl
Biological Process positive regulation of gene expression Source:ParkinsonsUK-UCL1 Publication
Biological Process positive regulation of Wnt signaling pathway Source:Ensembl
Biological Process regulation of neurogenesis Source:ParkinsonsUK-UCL1 Publication
Biological Process Spemann organizer formation at the anterior end of the primitive streak Source:Ensembl
Biological Process stem cell proliferation Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Secreted
Involvement in disease
Tetraamelia syndrome 1 (TETAMS1):
A form of tetraamelia, a rare disease characterized by rudimentary appendages or complete absence of all four limbs, and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. TETAMS1 patients manifest complete limb agenesis without defects of scapulae or clavicles. Other features include bilateral cleft lip/palate, diaphragmatic defect with bilobar right lung, renal and adrenal agenesis, pelvic hypoplasia, and urogenital defects. TETAMS1 transmission pattern is consistent with autosomal recessive inheritance.
PTM
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Anti-WNT3 antibodies

+ Filters
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Target: WNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C5
Application*: P, WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJW-172
Application*: IH, WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJW-171
Application*: WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJW-170
Application*: WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBWJW-213
Application*: WB, E
Target: WNT3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3G5
Application*: P, WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F5
Application*: WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D4
Application*: WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2A4
Application*: WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G7
Application*: WB, IH
Target: WNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F6
Application*: P, WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D9
Application*: WB
Target: WNT3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C7
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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