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VWF

This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]
Full Name
Von Willebrand Factor
Function
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Biological Process
Biological Process blood coagulation Source:UniProtKB1 Publication
Biological Process cell adhesion Source:UniProtKB1 Publication
Biological Process cell-substrate adhesion Source:UniProtKB1 Publication
Biological Process hemostasis Source:UniProtKB1 Publication
Biological Process platelet activation Source:UniProtKB1 Publication
Biological Process positive regulation of intracellular signal transduction Source:ARUK-UCL1 Publication
Biological Process response to wounding Source:UniProtKB1 Publication
Cellular Location
Secreted
Secreted, extracellular space, extracellular matrix
Localized to storage granules.
Involvement in disease
von Willebrand disease 1 (VWD1):
A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.
von Willebrand disease 2 (VWD2):
A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in altered platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet-dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma.
von Willebrand disease 3 (VWD3):
A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.
PTM
All cysteine residues are involved in intrachain or interchain disulfide bonds.
N- and O-glycosylated.

Anti-VWF antibodies

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Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: WFA52-2
Application*: WB, P, IF/IC, F
Target: VWF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: VWF/1859R
Application*: IF, IH, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: VW92-3
Application*: WB, E, P, C
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: rVWF/1465
Application*: IF, IH, IP, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GMA-022
Application*: WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: F8/86
Application*: P, C
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: VWF635
Application*: E, F, IF, WB, IP, IH
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM577
Application*: F, IF, WB, IP, IH
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: F8/44/20
Application*: WB, E
Target: VWF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EPSISR15
Application*: WB, IF/IC
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E2D10 + VWF635
Application*: WB, F, IC/IF, IP, P, C
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E2D10
Application*: WB, IP, P, C, F, IC/IF
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8D3
Application*: ELISA, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb363
Application*: FC, IF, IHC-P, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: R/2
Application*: E, F, IH, IF, IP, FN, R, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: R/1
Application*: E, F, IF, FN, R, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBXF-1040
Application*: WB, IC, P, C, E
Target: VWF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1039
Application*: WB, IC, P, C, E
Target: VWF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 05
Application*: E
Target: VWF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G1
Application*: WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D3
Application*: WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D7
Application*: WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 907CT12.1.9
Application*: WB, E, IH, F
Target: VWF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D8L8G
Application*: WB, IP, P
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6C7
Application*: P
Target: VWF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2H9
Application*: P
Target: VWF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2D11
Application*: IH, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F214
Application*: E, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCV-146
Application*: E, P, WB, IH
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 21-43
Application*: E, IF, IH, IP, R
Target: VWF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 13j100
Application*: E, IC, IH, WB
Target: VWF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCV-142
Application*: E, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RFF-VIII R/1
Application*: E, P, R
Target: VWF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYCV-141
Application*: E, P, C, IF, IC, IP, R
Target: VWF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCV-140
Application*: E
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5E7
Application*: E
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F215
Application*: E
Target: VWF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCV-139
Application*: E
Target: VWF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7G2B11C10
Application*: E, P
Target: VWF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 111
Application*: E, P
Target: VWF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A11
Application*: E, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCV-106
Application*: E, WB
Target: VWF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 14D209
Application*: F, IC, IF, IH
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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