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VTCN1

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Full Name

V-set domain containing T cell activation inhibitor 1

Function

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Biological Process

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process negative regulation of T cell activation Source:UniProtKB1 Publication
Biological Process negative regulation of T cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of interleukin-2 production Source:Ensembl
Biological Process positive regulation of T cell proliferation Source:Ensembl
Biological Process regulation of cytokine production Source:GO_Central1 Publication
Biological Process response to protozoan Source:Ensembl
Biological Process T cell receptor signaling pathway Source:GO_Central1 Publication

Cellular Location

Cell membrane
Expressed at the cell surface. A soluble form has also been detected.

Topology

Extracellular: 25-259
Helical: 260-280
Cytoplasmic: 281-282

PTM

N-glycosylated.

Anti-VTCN1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rabbit Anti-VTCN1 Recombinant Antibody (CBR043F) (CBMAB-BT098LY)

SDS

Target: VTCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBR043F

Application*: WB, IP, IHC, ICC, IHC-IF

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1831) (CBMAB-2180-YY)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1831

Application*: F, IH

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1766) (CBMAB-2115-YY)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-1766

Application*: F, MC

Rat Anti-VTCN1 Recombinant Antibody (CBYY-1731) (CBMAB-2080-YY)

SDS

Target: VTCN1

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBYY-1731

Application*: F, WB

Rabbit Anti-VTCN1 Recombinant Antibody (CBYY-1526) (CBMAB-1596-YY)

SDS

Target: VTCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBYY-1526

Application*: WB, IP, P, IC

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1525) (CBMAB-1595-YY)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1525

Application*: F

Mouse Anti-VTCN1 Recombinant Antibody (CBYY-1524) (CBMAB-1594-YY)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-1524

Application*: F

Rat Anti-VTCN1 Recombinant Antibody (CBYY-1523) (CBMAB-1593-YY)

SDS

Target: VTCN1

Host: Rat

Specificity: Mouse

Clone: CBYY-1523

Application*: F

Rabbit Anti-VTCN1 Recombinant Antibody (D1M8I) (CBMAB-V0092-YC)

SDS

Target: VTCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D1M8I

Application*: WB, P

Mouse Anti-VTCN1 Recombinant Antibody (10B249) (CBMAB-V0091-YC)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B249

Application*: F, IH

Mouse Anti-VTCN1 Recombinant Antibody (MIH43) (CBMAB-V0090-YC)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MIH43

Application*: F, C, P

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-131) (CBMAB-V0089-YC)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCV-131

Application*: E

Mouse Anti-VTCN1 Recombinant Antibody (13j96) (CBMAB-V0088-YC)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 13j96

Application*: E, IC, IH, WB

Rabbit Anti-VTCN1 Recombinant Antibody (CBYCV-130) (CBMAB-V0087-YC)

SDS

Target: VTCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYCV-130

Application*: WB, IP, P, IC

Rabbit Anti-VTCN1 Recombinant Antibody (CBYCV-129) (CBMAB-V0086-YC)

SDS

Target: VTCN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBYCV-129

Application*: E, WB

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-104) (CBMAB-V0014-YC)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCV-104

Application*: E, WB

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-103) (CBMAB-V0013-YC)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCV-103

Application*: IC, C, P, E, WB

Rat Anti-VTCN1 Recombinant Antibody (AL-01) (CBMAB-V0012-YC)

SDS

Target: VTCN1

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: AL-01

Application*: F

Mouse Anti-VTCN1 Recombinant Antibody (CBYCV-102) (CBMAB-V0011-YC)

SDS

Target: VTCN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCV-102

Application*: WB

Rat Anti-VTCN1 Recombinant Antibody (188) (CBMAB-V0009-YC)

SDS

Target: VTCN1

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: 188

Application*: F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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