VSIG4

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

V-Set And Immunoglobulin Domain Containing 4

Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

Biological Process complement activation, alternative pathway Source:UniProtKB-KW
Biological Process negative regulation of complement activation, alternative pathway Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-2 production Source:GO_Central1 Publication
Biological Process negative regulation of macrophage activation Source:InterPro
Biological Process negative regulation of T cell proliferation Source:GO_Central1 Publication

Membrane

Extracellular: 20-283
Helical: 284-304
Cytoplasmic: 305-399