VPS33B

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq]

vacuolar protein sorting 33 homolog B (yeast)

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358).
Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753).
Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity).

Biological Process collagen fibril organization Source:Ensembl
Biological Process collagen metabolic process Source:MGI1 Publication
Biological Process endosome organization Source:UniProtKB1 Publication
Biological Process intracellular protein transport Source:GO_Central1 Publication
Biological Process intracellular transport Source:ComplexPortal1 Publication
Biological Process lysosome localization Source:UniProtKB1 Publication
Biological Process megakaryocyte development Source:Ensembl
Biological Process melanosome localization Source:UniProtKB1 Publication
Biological Process membrane fusion Source:UniProtKB1 Publication
Biological Process peptidyl-lysine hydroxylation Source:MGI1 Publication
Biological Process phagosome-lysosome fusion Source:ComplexPortal1 Publication
Biological Process platelet alpha granule organization Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB1 Publication
Biological Process regulation of platelet aggregation Source:Ensembl
Biological Process vesicle-mediated transport Source:MGI1 Publication

Late endosome membrane
Lysosome membrane
Early endosome
Cytoplasmic vesicle, clathrin-coated vesicle
Recycling endosome
Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425).
Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090).
Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634).
Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358).

Arthrogryposis, renal dysfunction and cholestasis syndrome 1 (ARCS1):
A multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with bile duct hypoplasia and low gamma glutamyl transpeptidase activity. Platelet dysfunction is common.

Phosphorylated on tyrosine residues.
(Microbial infection) Dephosphorylated by M.tuberculosis PtpA, which induces the reduction of host phagolysosome fusion in M.tuberculosis-infected macrophages.