VEGFB

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

Vascular Endothelial Growth Factor B

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

Biological Process cardiac muscle contraction Source:Ensembl
Biological Process coronary vasculature development Source:Ensembl
Biological Process induction of positive chemotaxis Source:UniProtKB1 Publication
Biological Process negative regulation of apoptotic process Source:UniProtKB
Biological Process negative regulation of gene expression Source:UniProtKB
Biological Process negative regulation of neuron apoptotic process Source:UniProtKB
Biological Process positive regulation of angiogenesis Source:GO_Central1 Publication
Biological Process positive regulation of cell division Source:UniProtKB-KW
Biological Process positive regulation of endothelial cell proliferation Source:UniProtKB1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascade Source:UniProtKB
Biological Process positive regulation of mast cell chemotaxis Source:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-tyrosine phosphorylation Source:UniProtKB
Biological Process positive regulation of protein kinase B signaling Source:UniProtKB
Biological Process positive regulation of protein phosphorylation Source:GO_Central1 Publication
Biological Process positive regulation of vascular endothelial growth factor receptor signaling pathway Source:UniProtKB
Biological Process positive regulation of vascular wound healing Source:UniProtKB
Biological Process protein O-linked glycosylation Source:Ensembl
Biological Process response to hypoxia Source:GO_Central1 Publication
Biological Process sprouting angiogenesis Source:GO_Central1 Publication
Biological Process vascular endothelial growth factor receptor signaling pathway Source:GO_Central1 Publication
Biological Process vascular endothelial growth factor signaling pathway Source:GO_Central1 Publication

Secreted
Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

VEGF-B186 is O-glycosylated.