VAV2

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

VAV2

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process lamellipodium assembly Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of phosphatidylinositol 3-kinase activity Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome

cytoplasm
cytosol
plasma membrane

Phosphorylated on tyrosine residues in response to FGR activation.