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Mouse Anti-VAV2 Antibody (8B7) (CBMAB-1807CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
8B7
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein (aa 665-805; SH2 domain)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
VAV2
Introduction
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. It plays an important role in angiogenesis. Diseases associated with VAV2 include Glaucoma, Normal Tension and Agenesis Of The Corpus Callosum With Peripheral Neuropathy. Among its related pathways are p75 NTR receptor-mediated signalling and Focal Adhesion.
Entrez Gene ID
7410
UniProt ID
P52735
Alternative Names
VAV-2
Function
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process lamellipodium assembly Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of phosphatidylinositol 3-kinase activity Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome
Cellular Location
cytoplasm
cytosol
plasma membrane
PTM
Phosphorylated on tyrosine residues in response to FGR activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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