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USP13

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves Lys-63-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Full Name
Ubiquitin Specific Peptidase 13
Function
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Also regulates ERAD through the deubiquitination of UBL4A a component of the BAG6/BAT3 complex. Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.
Biological Process
Biological Process autophagy Source:UniProtKB-KW
Biological Process cell population proliferation Source:UniProtKB1 Publication
Biological Process maintenance of unfolded protein involved in ERAD pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process melanocyte differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of ERAD pathway Source:ParkinsonsUK-UCL1 Publication
Biological Process protein deubiquitination Source:GO_Central1 Publication
Biological Process protein K29-linked deubiquitination Source:MGI1 Publication
Biological Process protein K6-linked deubiquitination Source:MGI1 Publication
Biological Process protein K63-linked deubiquitination Source:UniProtKB1 Publication
Biological Process protein stabilization Source:UniProtKB1 Publication
Biological Process regulation of autophagy Source:UniProtKB1 Publication
Biological Process regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
cytosol
nucleoplasm
nucleus

Anti-USP13 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: USP13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-254
Application*: E, IF, IH, WB
Target: USP13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF467
Application*: ELISA, WB, IHC, IF
Target: USP13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4G1
Application*: IH, P, WB
Target: USP13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey
Clone: 4G11
Application*: P, IP, WB
Target: USP13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B9
Application*: IP, WB
Target: USP13
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXU-014
Application*: WB, IP, IF, E
Target: USP13
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXU-015
Application*: WB, IP, IF, E
Target: USP13
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXU-031
Application*: WB, IP, IC, F
Target: USP13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXU-068
Application*: E, WB, IH, IF
Target: USP13
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXU-156
Application*: WB
Target: USP13
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H7
Application*: IP, E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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