Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

UNC13D

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq]
Full Name
unc-13 homolog D (C. elegans)
Function
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.
Biological Process
Biological Process defense response to virus Source:Ensembl
Biological Process germinal center formation Source:Ensembl
Biological Process granuloma formation Source:Ensembl
Biological Process natural killer cell degranulation Source:Ensembl
Biological Process phagocytosis Source:Ensembl
Biological Process positive regulation of exocytosis Source:UniProtKB2 Publications
Biological Process positive regulation of regulated secretory pathway Source:UniProtKB1 Publication
Biological Process positive regulation of substrate adhesion-dependent cell spreading Source:Ensembl
Biological Process regulation of mast cell degranulation Source:UniProtKB1 Publication
Biological Process secretion Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Membrane
Late endosome
Recycling endosome
Lysosome
Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.
Involvement in disease
Hemophagocytic lymphohistiocytosis, familial, 3 (FHL3):
A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.

Anti-UNC13D antibodies

+ Filters
Loading...
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: UNC13D
Host: Rabbit
Specificity: Human
Clone: CBCNC-793
Application*: FC, ICC, P, WB
Target: UNC13D
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 2C7
Application*: E, WB
Target: UNC13D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F4
Application*: WB
Target: UNC13D
Host: Mouse
Specificity: Human
Clone: 1E11
Application*: E, WB
Target: UNC13D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 1224B
Application*: WB
Target: UNC13D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1223A
Application*: WB, ICC
Target: UNC13D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 1222B
Application*: WB, ICC
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Online Inquiry