UBE2E2

UBE2E2 (Ubiquitin Conjugating Enzyme E2 E2) accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. Among its related pathways are Class I MHC mediated antigen processing and presentation and Ubiquitin mediated proteolysis. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity.

UBE2E2

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

Biological Process cellular response to DNA damage stimulus Source:MGI1 Publication
Biological Process ISG15-protein conjugation Source:HGNC-UCL1 Publication
Biological Process positive regulation of G1/S transition of mitotic cell cycle Source:MGI1 Publication
Biological Process protein K11-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication

Nucleus

Autoubiquitinated in vitro.