TYRO3

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

TYRO3 Gene(Protein Coding) TYRO3 Protein Tyrosine Kinase

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.

Biological Process apoptotic cell clearance Source:UniProtKB
Biological Process cell adhesion Source:UniProtKB1 Publication
Biological Process cell migration Source:GO_Central1 Publication
Biological Process establishment of localization in cell Source:Ensembl
Biological Process forebrain cell migration Source:UniProtKB
Biological Process natural killer cell differentiation Source:Ensembl
Biological Process negative regulation of inflammatory response Source:UniProtKB
Biological Process negative regulation of innate immune response Source:UniProtKB
Biological Process negative regulation of lymphocyte activation Source:Ensembl
Biological Process negative regulation of neuron apoptotic process Source:UniProtKB
Biological Process negative regulation of toll-like receptor signaling pathway Source:UniProtKB
Biological Process nervous system development Source:GO_Central1 Publication
Biological Process neuron apoptotic process Source:Ensembl
Biological Process neuron cellular homeostasis Source:UniProtKB
Biological Process neuron migration Source:Ensembl
Biological Process neuropeptide signaling pathway Source:Ensembl
Biological Process ovulation cycle Source:UniProtKB
Biological Process phagocytosis Source:GO_Central1 Publication
Biological Process phosphatidylinositol 3-kinase signaling Source:UniProtKB1 Publication
Biological Process platelet activation Source:UniProtKB
Biological Process platelet aggregation Source:UniProtKB
Biological Process positive regulation of kinase activity Source:GO_Central1 Publication
Biological Process positive regulation of viral life cycle Source:FlyBase1 Publication
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process protein kinase B signaling Source:UniProtKB
Biological Process secretion by cell Source:UniProtKB
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process spermatogenesis Source:UniProtKB
Biological Process substrate adhesion-dependent cell spreading Source:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathway Source:GO_Central1 Publication
Biological Process vagina development Source:Ensembl

Cell membrane

Extracellular: 41-429
Helical: 430-450
Cytoplasmic: 451-890

Autophosphorylated.