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TYMP

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]

Full Name

TYMP Gene(Protein Coding) Thymidine Phosphorylase

Function

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Biological Process

Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process chemotaxis Source:UniProtKB-KW
Biological Process dTMP catabolic process Source:Ensembl
Biological Process mitochondrial genome maintenance Source:CAFA1 Publication
Biological Process pyrimidine nucleobase metabolic process Source:InterPro
Biological Process pyrimidine nucleoside metabolic process Source:CAFA1 Publication
Biological Process regulation of gastric motility Source:CAFA1 Publication
Biological Process regulation of myelination Source:CAFA1 Publication
Biological Process regulation of transmission of nerve impulse Source:CAFA1 Publication

Cellular Location

Cytosol

Involvement in disease

Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1):
A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy.

Anti-TYMP antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rabbit Anti-TYMP Recombinant Antibody (D69B12) (CBMAB-CP2830-LY)

SDS

Target: TYMP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D69B12

Application*: WB, IP

Recombinant Mouse Anti-TYMP Recombinant Antibody (44C) (CBMAB-XB1193-YC)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 44C

Application*: IH, IF, IP, WB

Mouse Anti-TYMP Recombinant Antibody (PGF 44C) (CBMAB-P3761-YC)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: PGF 44C

Application*: WB, IH, P

Mouse Anti-TYMP Recombinant Antibody (6A162) (CBMAB-P3760-YC)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6A162

Application*: IH, IP, WB

Mouse Anti-TYMP Recombinant Antibody (SPM322) (CBMAB-T5136-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: SPM322

Application*: WB, P, IP

Mouse Anti-TYMP Recombinant Antibody (P-GF.44C) (CBMAB-T5135-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: P-GF.44C

Application*: C, P, WB

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5518) (CBMAB-T5134-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: CBYJT-5518

Application*: IH, N

Rabbit Anti-TYMP Recombinant Antibody (CBYJT-5517) (CBMAB-T5133-YJ)

SDS

Target: TYMP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-5517

Application*: IP, WB

Rabbit Anti-TYMP Recombinant Antibody (CBYJT-5516) (CBMAB-T5132-YJ)

SDS

Target: TYMP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-5516

Application*: WB, IP

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5515) (CBMAB-T5131-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5515

Application*: WB, IH

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5514) (CBMAB-T5130-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5514

Application*: WB, IH

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5513) (CBMAB-T5129-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5513

Application*: WB, IH

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5512) (CBMAB-T5128-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5512

Application*: WB, IH

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5511) (CBMAB-T5127-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5511

Application*: WB, IH

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5510) (CBMAB-T5126-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5510

Application*: WB, IH

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5509) (CBMAB-T5125-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5509

Application*: WB, IH

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5508) (CBMAB-T5124-YJ)

SDS

Target: TYMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-5508

Application*: WB, IH

Rabbit Anti-TYMP Recombinant Antibody (CBYJT-5507) (CBMAB-T5123-YJ)

SDS

Target: TYMP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-5507

Application*: IP, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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