TUBG1
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.
Full Name
TUBG1 Gene(Protein Coding) Tubulin Gamma 1
Alternative Names
TUBG1; CDCBM4; GCP-1; TUBG; TUBGCP1; tubulin gamma 1
Function
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
Biological Process
Biological Process cytoplasmic microtubule organization Source:InterPro
Biological Process meiotic spindle organization Source:UniProtKB
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process microtubule nucleation Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:GO_Central1 Publication
Biological Process mitotic sister chromatid segregation Source:GO_Central1 Publication
Biological Process mitotic spindle organization Source:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Localizes to mitotic spindle microtubules.
Involvement in disease
Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4):
A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients.
PTM
Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
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