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TSC22D3

This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Full Name

TSC22D3 Gene(Protein Coding) TSC22 Domain Family Member 3

Function

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

Biological Process

Biological Process negative regulation of activation-induced cell death of T cells Source:Ensembl
Biological Process regulation of transcription by RNA polymerase II Source:InterPro
Biological Process response to osmotic stress Source:Ensembl

Cellular Location

Isoform 1
Cytoplasm
Nucleus
Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity).

Anti-TSC22D3 antibodies

Mouse Anti-TSC22D3 Recombinant Antibody (3A5) (CBMAB-G6661-LY)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3A5

Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBLG1-2460) (CBMAB-G6662-LY)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-2460

Application*: E, IF, P, WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBLG1-2461) (CBMAB-G6663-LY)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-2461

Application*: E, WB

Mouse Anti-TSC22D3 Recombinant Antibody (2B2) (CBMAB-A9561-LY)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2B2

Application*: WB, E

Mouse Anti-TSC22D3 Monoclonal Antibody (1G10) (CBMAB-0275-LY)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 1G10

Application*: IP, E

Mouse Anti-TSC22D3 Recombinant Antibody (CBYCD-524) (CBMAB-D2352-YC)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCD-524

Application*: WB, IC, P, C, E

Rat Anti-TSC22D3 Recombinant Antibody (CFMKG15) (CBMAB-H3891-FY)

SDS

Target: TSC22D3

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CFMKG15

Application*: WB, F

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4977) (CBMAB-T4534-YJ)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4977

Application*: WB, IH, IF

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4978) (CBMAB-T4535-YJ)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4978

Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4979) (CBMAB-T4536-YJ)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-4979

Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4980) (CBMAB-T4537-YJ)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4980

Application*: WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4981) (CBMAB-T4538-YJ)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4981

Application*: E, IF, IH, IP, WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4982) (CBMAB-T4539-YJ)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-4982

Application*: IF, WB

Mouse Anti-TSC22D3 Recombinant Antibody (CBYJT-4983) (CBMAB-T4540-YJ)

SDS

Target: TSC22D3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-4983

Application*: WB

TSC22D3 Matched Antibody Pair (1281) (APMAB-1281LY)

SDS

Target: TSC22D3

Specificity: Human

TSC22D3 Matched Antibody Pair (1282) (APMAB-1282LY)

SDS

Target: TSC22D3

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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