TRIM27

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

TRIM27

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).
Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Biological Process Arp2/3 complex-mediated actin nucleation Source:UniProtKB1 Publication
Biological Process innate immune response Source:UniProtKB1 Publication
Biological Process negative regulation of adaptive immune response Source:UniProtKB1 Publication
Biological Process negative regulation of calcium ion import Source:UniProtKB1 Publication
Biological Process negative regulation of gene expression, epigenetic Source:MGI1 Publication
Biological Process negative regulation of interleukin-2 production Source:UniProtKB1 Publication
Biological Process negative regulation of protein kinase activity Source:UniProtKB1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:MGI1 Publication
Biological Process negative regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process negative regulation of viral transcription Source:UniProtKB1 Publication
Biological Process positive regulation of actin nucleation Source:Ensembl
Biological Process positive regulation of autophagy Source:GO_Central1 Publication
Biological Process positive regulation of DNA-binding transcription factor activity Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process positive regulation of interferon-gamma production Source:UniProtKB1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:GO_Central1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of protein localization Source:GO_Central1 Publication
Biological Process regulation of viral entry into host cell Source:GO_Central1 Publication
Biological Process retrograde transport, endosome to Golgi Source:UniProtKB1 Publication
Biological Process spermatogenesis Source:ProtInc1 Publication
Biological Process suppression of viral release by host Source:Ensembl

Nucleus
Cytoplasm
Nucleus, PML body
Early endosome
Nuclear or cytoplasmic depending on the cell type (By similarity).
Colocalized with PML and EIF3S6 in nuclear bodies. Recruited to retromer-containing endosomes via interaction with MAGEL2 (PubMed:23452853).

A chromosomal aberration involving TRIM27/RFP is found in papillary thyroid carcinomas (PTCs). Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes.