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TP73

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Full Name
TP73
Function
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity).
It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cellular response to DNA damage stimulus Source:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage Source:ProtInc1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source:UniProtKB2 Publications
Biological Process kidney development Source:Ensembl
Biological Process mismatch repair Source:ProtInc1 Publication
Biological Process negative regulation of cardiac muscle cell proliferation Source:MGI1 Publication
Biological Process negative regulation of cell population proliferation Source:AgBase
Biological Process negative regulation of neuron differentiation Source:Ensembl
Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of lung ciliated cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of MAPK cascade Source:Ensembl
Biological Process positive regulation of oligodendrocyte differentiation Source:Ensembl
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB3 Publications
Biological Process protein tetramerization Source:InterPro
Biological Process regulation of cell cycle Source:ParkinsonsUK-UCL1 Publication
Biological Process regulation of gene expression Source:MGI1 Publication
Biological Process regulation of mitotic cell cycle Source:MGI1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:GO_Central1 Publication
Biological Process response to organonitrogen compound Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Cellular Location
Nucleus
Cytoplasm
Accumulates in the nucleus in response to DNA damage.
Involvement in disease
Ciliary dyskinesia, primary, 47, and lissencephaly (CILD47):
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD47 is an autosomal recessive form characterized by onset soon after birth or in early childhood. Affected individuals also have neurologic features, such as impaired intellectual development and central hypotonia, associated with structural brain abnormalities, most notably lissencephaly and thin or absent corpus callosum. No situs abnormalities have been observed.
PTM
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.
Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.

Anti-TP73 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: TP73
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 38C674
Application*: WB, P, C, F, CI, IC, IF
Target: TP73
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: ER-15
Application*: WB, IF, IC, IP
Target: TP73
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4291
Application*: WB, IH, IF
Target: TP73
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4292
Application*: P, WB
Target: TP73
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5B429
Application*: CI, IC, IF, C, P, IP, WB
Target: TP73
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5B789
Application*: WB
Target: TP73
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4293
Application*: E, IH, WB
Target: TP73
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 5B1288
Application*: WB, CI, IF, IP
Target: TP73
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJT-4294
Application*: IC, P, IP, WB
Target: TP73
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-4295
Application*: CI, P, WB
Target: TP73
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 38C674.2
Application*: WB, CI, IC, IF, IP, P, C
Target: TP73
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4288
Application*: WB, IH, IF
Target: TP73
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4289
Application*: WB, IH, IF
Target: TP73
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4290
Application*: WB, IH
Target: TP73
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Monkey
Clone: CBYJT-4296
Application*: GS, IF, IP, WB
Target: TP73
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D3G10
Application*: WB, IP, IF (IC)
Target: TP73
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1A8
Application*: IP, M, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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