TNNT3

The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity.

TNNT3

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process positive regulation of calcium-dependent ATPase activity Source:UniProtKB2 Publications
Biological Process regulation of ATP-dependent activity Source:UniProtKB1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process skeletal muscle contraction Source:UniProtKB1 Publication

cytosol
troponin complex

rthrogryposis, distal, 2B2 (DA2B2):
A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 2 is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. DA2B2 inheritance is autosomal dominant.