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TNNT2

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq]
Full Name
troponin T type 2 (cardiac)
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process actin crosslink formation Source:Ensembl
Biological Process cardiac muscle contraction Source:CAFA1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process muscle filament sliding Source:UniProtKB2 Publications
Biological Process negative regulation of ATP-dependent activity Source:UniProtKB1 Publication
Biological Process positive regulation of ATP-dependent activity Source:UniProtKB2 Publications
Biological Process regulation of heart contraction Source:UniProtKB1 Publication
Biological Process regulation of muscle filament sliding speed Source:Ensembl
Biological Process response to calcium ion Source:UniProtKB1 Publication
Biological Process sarcomere organization Source:GO_Central1 Publication
Biological Process ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication
Cellular Location
cardiac myofibril
cardiac Troponin complex
cytosol
sarcomere
striated muscle thin filament
troponin complex
Involvement in disease
Cardiomyopathy, familial hypertrophic 2 (CMH2):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Cardiomyopathy, dilated 1D (CMD1D):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial restrictive 3 (RCM3):
A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
PTM
Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.

Anti-TNNT2 antibodies

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Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Pig, Cattle, Dog, Cat, Fish, Goat, Rabbit
Clone: CBYJT-4103
Application*: SE
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Mouse, Rat, Rabbit, Chicken, Monkey, Dog, Horse, Sheep
Clone: CBYJT-4102
Application*: P, IF, IC
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Cattle, Cat, Dog, Goat, Mouse, Pig, Rabbit, Rat
Clone: CBYJT-4101
Application*: E, WB, IH, IP
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4567
Application*: E, P
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Chicken
Clone: CBWJC-4564
Application*: WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4563
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9g6
Application*: E
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4562
Application*: E, C, P, IP, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Chicken, Fish, Human, Mouse, Rabbit, Rat, Frog
Clone: CT3
Application*: P, IF, IH, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4096
Application*: WB, E
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-4095
Application*: IO, SE
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Chicken
Clone: CBYJT-4108
Application*: WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4094
Application*: E, WB, P, IF, IC, F
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Cat, Goat, Human, Rabbit
Clone: CBYJT-4093
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: CBYJT-4092
Application*: E, IP, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit, Cattle, Chicken, Dog, Horse, Human, Monkey, Mouse, Rat, Sheep
Clone: CBYJT-4107
Application*: IF, IH
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit, Chicken, Rat
Clone: CBYJT-4106
Application*: P, C, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rabbit
Clone: CBYJT-4105
Application*: IF, IH
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4104
Application*: IH
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M40283
Application*: E, IH
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: M401134
Application*: E
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M322512
Application*: E
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4099
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G1
Application*: E, C, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Fish, Goat, Mouse, Pig, Rabbit, Rat
Clone: 2F3
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat, Rabbit, Goat, Cattle, Dog, Human, Pig
Clone: 2G3
Application*: WB, E, AP
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4098
Application*: WB, E, IH
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H4-F7
Application*: WB, E
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Human
Clone: T1/61
Application*: E, C, P, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TT44 BGN/1288/44
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Dog, Goat, Human, Mouse, Pig, Rabbit, Rat
Clone: n.a
Application*: E, IP, P, WB
Target: TNNT2
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXC-0839
Application*: F
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0703
Application*: E, P
Target: TNNT2
Host: Mouse
Specificity: Rat
Clone: CBCNC-719
Application*: WB, ICC, P, IH-F, E
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-720
Application*: E, WB, P, R
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Human, Chicken, Dog, Guinea pig, Pig, Rabbit, Rat
Clone: 13-11
Application*: C, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C11
Application*: WB, IP, E, C, P, C, AP, IC/IF, SE
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 200805
Application*: IH, IC
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Chicken, Guinea pig, Dog, Human, Pig, Sheep
Clone: 0.N.590
Application*: WB, P, EM, IC/IF
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Dog, Pig, Rat, Sheep, Goat, Rabbit
Clone: 1A11
Application*: E, R, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Dog, Pig, Rat, Sheep, Goat, Rabbit
Clone: 1F11
Application*: E, R, IC/IF, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Dog, Fish, Goat, Human, Rabbit
Clone: 1F2
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B10-G11
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Chicken, Guinea pig, Dog, Human, Pig, Sheep
Clone: 42321
Application*: P, IC/IF
Target: TNNT2
Host: Mouse
Antibody Isotype: IgM
Specificity: Dog
Clone: 5C12
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2025
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rabbit, Goat, Cattle, Dog, Human, Fish
Clone: CBYY-C2026
Application*: WB, E, P, C, AP
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2027
Application*: WB, E, S-E
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Goat, Cattle, Dog, Human, Pig
Clone: 3D6
Application*: WB, E, P, C, AP
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Goat, Rabbit
Clone: 7A9
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7E7
Application*: E, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Pig
Clone: 7F4
Application*: E, R, WB
Target: TNNT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog
Clone: 7G7
Application*: E, R, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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