TNFRSF1B

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

TNFRSF1B Gene(Protein Coding) TNF Receptor Superfamily Member 1B

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Biological Process aging Source:Ensembl
Biological Process aortic valve development Source:BHF-UCL
Biological Process cellular response to growth factor stimulus Source:Ensembl
Biological Process cellular response to lipopolysaccharide Source:BHF-UCL1 Publication
Biological Process extrinsic apoptotic signaling pathway Source:GO_Central1 Publication
Biological Process glial cell-neuron signaling Source:ARUK-UCL
Biological Process immune response Source:Ensembl
Biological Process inflammatory response Source:Ensembl
Biological Process intrinsic apoptotic signaling pathway in response to DNA damage Source:GO_Central1 Publication
Biological Process negative regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process negative regulation of cell death Source:ARUK-UCL
Biological Process negative regulation of extracellular matrix constituent secretion Source:BHF-UCL
Biological Process negative regulation of neuroinflammatory response Source:ARUK-UCL
Biological Process negative regulation of neuron death Source:ARUK-UCL
Biological Process positive regulation of apoptotic process involved in morphogenesis Source:BHF-UCL
Biological Process positive regulation of membrane protein ectodomain proteolysis Source:BHF-UCL1 Publication
Biological Process positive regulation of myelination Source:ARUK-UCL
Biological Process positive regulation of oligodendrocyte differentiation Source:ARUK-UCL
Biological Process pulmonary valve development Source:BHF-UCL
Biological Process regulation of cytokine production involved in immune response Source:ARUK-UCL
Biological Process regulation of myelination Source:ARUK-UCL
Biological Process regulation of neuroinflammatory response Source:ARUK-UCL
Biological Process regulation of RNA biosynthetic process Source:ARUK-UCL
Biological Process regulation of T cell cytokine production Source:ARUK-UCL
Biological Process regulation of T cell proliferation Source:ARUK-UCL
Biological Process RNA destabilization Source:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathway Source:ARUK-UCL1 Publication

Isoform 1
Cell membrane
Isoform 2
Secreted
Tumor necrosis factor-binding protein 2
Secreted

Extracellular: 23-257
Helical: 258-287
Cytoplasmic: 288-461

Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.