TMPRSS15

TMPRSS15 is an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.

Transmembrane Protease, Serine 15

Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.

Proteolysis

Membrane

Enterokinase deficiency (ENTKD):
Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.

Cytoplasmic: 2-18
Helical: 19-47
Extracellular: 48-1019

The chains are derived from a single precursor that is cleaved by a trypsin-like protease.