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Mouse Anti-TMPRSS15 Recombinant Antibody (CBYJT-3558) (CBMAB-T2885-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3558
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transmembrane Protease, Serine 15
Introduction
TMPRSS15 is an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. TMPRSS15 is cleaved into two chains that form a heterodimer linked by a disulfide bond. TMPRSS15 is a member of the trypsin family of peptidases. Mutations in TMPRSS15 cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive.
Entrez Gene ID
5651
UniProt ID
P98073
Alternative Names
Transmembrane Protease, Serine 15; Protease, Serine, 7 (Enterokinase); Serine Protease 7; Enteropeptidase; EC 3.4.21.9; PRSS7; ENTK
Function
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
Biological Process
Proteolysis
Cellular Location
Membrane
Involvement in disease
Enterokinase deficiency (ENTKD):
Life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive.
Topology
Cytoplasmic: 2-18
Helical: 19-47
Extracellular: 48-1019
PTM
The chains are derived from a single precursor that is cleaved by a trypsin-like protease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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