TLR1

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

TLR1 Gene(Protein Coding) Toll Like Receptor 1

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852).
Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Biological Process cell activationSource:AgBase1 Publication
Biological Process cellular response to bacterial lipopeptideSource:GO_Central1 Publication
Biological Process cellular response to triacyl bacterial lipopeptideSource:UniProtKB1 Publication
Biological Process detection of triacyl bacterial lipopeptideSource:MGI1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal2 Publications
Biological Process macrophage activationSource:UniProtKB1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-6 productionSource:UniProtKBBy Similarity
Biological Process positive regulation of interleukin-8 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of toll-like receptor 2 signaling pathwaySource:ARUK-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKBBy Similarity
Biological Process signal transductionSource:ProtInc2 Publications
Biological Process toll-like receptor 1 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:ComplexPortal1 Publication

Cell membrane
Cytoplasmic vesicle, phagosome membrane
Membrane raft
Golgi apparatus
Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.

Extracellular: 25-580
Helical: 581-601
Cytoplasmic: 602-786