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Rat Anti-Tlr1 Recombinant Antibody (CBYJT-3344) (CBMAB-T2637-YJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-3344
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TLR1 Gene(Protein Coding) Toll Like Receptor 1
Introduction
Tlr1 participates in the innate immune response to microbial agents. It specifically recognizes diacylated and triacylated lipopeptides. Tlr1 cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. It forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Tlr1 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Tlr1 acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen.
Entrez Gene ID
21897
UniProt ID
Q9EPQ1
Alternative Names
toll-like receptor 1; TIL; toll/interleukin-1 receptor-like protein
Function
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852).
Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211).
Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Biological Process
Biological Process cell activationSource:AgBase1 Publication
Biological Process cellular response to bacterial lipopeptideSource:GO_Central1 Publication
Biological Process cellular response to triacyl bacterial lipopeptideSource:UniProtKB1 Publication
Biological Process detection of triacyl bacterial lipopeptideSource:MGI1 Publication
Biological Process immune responseSource:ProtInc1 Publication
Biological Process inflammatory responseSource:GO_Central1 Publication
Biological Process innate immune responseSource:ComplexPortal2 Publications
Biological Process macrophage activationSource:UniProtKB1 Publication
Biological Process MyD88-dependent toll-like receptor signaling pathwaySource:InterPro
Biological Process positive regulation of interleukin-6 productionSource:UniProtKBBy Similarity
Biological Process positive regulation of interleukin-8 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of toll-like receptor 2 signaling pathwaySource:ARUK-UCL1 Publication
Biological Process positive regulation of tumor necrosis factor productionSource:UniProtKBBy Similarity
Biological Process signal transductionSource:ProtInc2 Publications
Biological Process toll-like receptor 1 signaling pathwaySource:InterPro
Biological Process toll-like receptor signaling pathwaySource:ComplexPortal1 Publication
Cellular Location
Cell membrane
Cytoplasmic vesicle, phagosome membrane
Membrane raft
Golgi apparatus
Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus.
Topology
Extracellular: 25-580
Helical: 581-601
Cytoplasmic: 602-786
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For research use only. Not intended for any clinical use.

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