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TK1

The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers.

Full Name

thymidine kinase 1

Function

Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153).
Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435).
Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) (PubMed:22385435).

Biological Process

Biological Process DNA biosynthetic processSource:UniProtKB-KW
Biological Process nucleobase-containing compound metabolic processSource:ProtInc1 Publication
Biological Process phosphorylationSource:UniProtKB-KW
Biological Process protein homotetramerizationSource:UniProtKB1 Publication
Biological Process thymidine metabolic processSource:UniProtKB1 Publication

Cellular Location

Cytoplasm

PTM

Phosphorylated on Ser-13 in mitosis. Phosphorylation of Ser-13 by CDK1 during mitosis reduces homotetramerization and catalytic efficiency when DNA replication is complete and intracellular TK1 is still present at a high level (PubMed:9575153, PubMed:14697231).
Polyubiquitinated. Postmitosis, ubiquitination leads to proteasomal degradation. The KEN box sequence located at the C-terminal region targets for degradation by the anaphase promoting complex (APC/C) activated and rate-limited by FZR1.

Anti-TK1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-TK1 Recombinant Antibody (3G11) (CBMAB-A9128-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G11

Application*: WB, E

Mouse Anti-TK1 Recombinant Antibody (3G10) (CBMAB-A9127-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3G10

Application*: WB, E

Mouse Anti-TK1 Recombinant Antibody (3F9) (CBMAB-A9126-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F9

Application*: WB, E

Mouse Anti-TK1 Recombinant Antibody (3A8) (CBMAB-A9125-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3A8

Application*: E, E

Mouse Anti-TK1 Recombinant Antibody (2G8) (CBMAB-A9124-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2G8

Application*: E, E

Mouse Anti-TK1 Recombinant Antibody (2F7) (CBMAB-A9123-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2F7

Application*: E, E

Mouse Anti-TK1 Recombinant Antibody (2A2) (CBMAB-A9122-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2A2

Application*: WB, E

Mouse Anti-TK1 Recombinant Antibody (1F12) (CBMAB-A9121-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F12

Application*: WB, E

Mouse Anti-TK1 Recombinant Antibody (1D10) (CBMAB-A9120-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1D10

Application*: WB, E

Mouse Anti-TK1 Recombinant Antibody (3E2) (CBMAB-A9119-LY)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3E2

Application*: WB, E

Rabbit Anti-TK1 Recombinant Antibody (EG1797) (CBMAB-EN2145-LY)

SDS

Target: TK1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1797

Application*: WB: 1:500~1:1000 ELISA: 1:1000

TK1 Matched Antibody Pair (1210) (APMAB-1210LY)

SDS

Target: TK1

Specificity: Human

TK1 Matched Antibody Pair (1209) (APMAB-1209LY)

SDS

Target: TK1

Specificity: Human

Mouse Anti-TK1 Recombinant Antibody (CBYJT-3269) (CBMAB-T2554-YJ)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJT-3269

Application*: WB, SE, E

Mouse Anti-TK1 Recombinant Antibody (CBYJT-3267) (CBMAB-T2552-YJ)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJT-3267

Application*: P, WB

Mouse Anti-TK1 Recombinant Antibody (CBYJT-3266) (CBMAB-T2551-YJ)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-3266

Application*: WB, IH, IP, E

Mouse Anti-TK1 Recombinant Antibody (CBYJT-3265) (CBMAB-T2550-YJ)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3265

Application*: E, WB

Mouse Anti-TK1 Recombinant Antibody (CBYJT-3264) (CBMAB-T2549-YJ)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3264

Application*: E, WB

Mouse Anti-TK1 Recombinant Antibody (CBYJT-3263) (CBMAB-T2547-YJ)

SDS

Target: TK1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3263

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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