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THRB

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Full Name
THRB Gene(Protein Coding) Thyroid Hormone Receptor Beta
Function
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Biological Process
Biological Process cell differentiationSource:GO_Central1 Publication
Biological Process cellular response to thyroid hormone stimulusSource:ARUK-UCL1 Publication
Biological Process DNA-templated transcriptionSource:ProtInc1 Publication
Biological Process female courtship behaviorSource:Ensembl
Biological Process hormone-mediated signaling pathwaySource:GO_Central1 Publication
Biological Process mRNA transcription by RNA polymerase IISource:ComplexPortal1 Publication
Biological Process negative regulation of female receptivitySource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:GO_Central1 Publication
Biological Process positive regulation of thyroid hormone mediated signaling pathwaySource:ComplexPortal1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:ComplexPortal1 Publication
Biological Process regulation of heart contractionSource:Ensembl
Biological Process retinal cone cell apoptotic processSource:Ensembl
Biological Process retinal cone cell developmentSource:Ensembl
Biological Process sensory perception of soundSource:Ensembl
Biological Process thyroid hormone mediated signaling pathwaySource:GO_Central1 Publication
Biological Process type I pneumocyte differentiationSource:Ensembl
Cellular Location
Nucleus
Involvement in disease
Thyroid hormone resistance, generalized, autosomal dominant (GRTHD):
An autosomal dominant disease characterized by high levels of circulating thyroid hormones (T3-T4), goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. Patients have normal or slightly elevated thyroid stimulating hormone (TSH).
Thyroid hormone resistance, generalized, autosomal recessive (GRTHR):
An autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone.
Selective pituitary thyroid hormone resistance (PRTH):
Variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.

Anti-THRB antibodies

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Target: THRB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-3040
Application*: WB, IP, IF, P
Target: THRB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBYJT-3039
Application*: WB, IP, IF, E
Target: THRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: J52
Application*: GS, IC, IF, IH, P, IP, WB, CI
Target: THRB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3038
Application*: WB, IP, E
Target: THRB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3037
Application*: WB, IP, IF
Target: THRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3036
Application*: GS, IC, IF, P, IH, IP, WB
Target: THRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Mouse, Rat
Clone: 2386
Application*: E, WB
Target: THRB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJN-1697
Application*: F, C, P, IP, WB
Target: THRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1696
Application*: WB
Target: THRB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1CT11
Application*: E, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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