TERF2IP

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]

TERF2IP

Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.

Biological Process negative regulation of DNA recombination at telomereSource:UniProtKB
Biological Process negative regulation of protein phosphorylationSource:CAFA1 Publication
Biological Process negative regulation of telomere maintenanceSource:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB
Biological Process positive regulation of NF-kappaB transcription factor activitySource:UniProtKB
Biological Process positive regulation of NIK/NF-kappaB signalingSource:CAFA1 Publication
Biological Process positive regulation of peptidyl-serine phosphorylationSource:UniProtKB1 Publication
Biological Process positive regulation of protein acetylationSource:UniProtKB1 Publication
Biological Process positive regulation of telomere maintenanceSource:ComplexPortal1 Publication
Biological Process protection from non-homologous end joining at telomereSource:BHF-UCL1 Publication
Biological Process protein localization to chromosome, telomeric regionSource:BHF-UCL1 Publication
Biological Process regulation of DNA-templated transcriptionSource:CAFA1 Publication
Biological Process regulation of double-strand break repair via homologous recombinationSource:UniProtKB
Biological Process regulation of telomere maintenanceSource:BHF-UCL1 Publication
Biological Process telomere cappingSource:ComplexPortal1 Publication
Biological Process telomere maintenanceSource:BHF-UCL1 Publication
Biological Process telomere maintenance via telomeraseSource:ProtInc1 Publication
Biological Process telomere maintenance via telomere lengtheningSource:UniProtKB

Nucleus
Cytoplasm
Chromosome
Chromosome, telomere
Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex.