TBCB

TBCB (Tubulin Folding Cofactor B) is a Protein Coding gene. Diseases associated with TBCB include Hypoparathyroidism-Retardation-Dysmorphism Syndrome. Among its related pathways are Metabolism of proteins and Chaperonin-mediated protein folding. An important paralog of this gene is CLIP2.

Full Name

TBCB Gene(Protein Coding) Tubulin Folding Cofactor B

Function

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649).
Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.

PTM

Phosphorylation by PAK1 is required for normal function.
Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.
(Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability.

Anti-TBCB antibodies

Mouse Anti-TBCB Recombinant Antibody (AT1F6) (CBMAB-1829-CN)

Datasheet

SDS

Target: TBCB

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: AT1F6

Application*: WB

Mouse Anti-TBCB Recombinant Antibody (CBYJT-2064) (CBMAB-T1161-YJ)

Datasheet

SDS

Target: TBCB

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-2064

Application*: E, WB

Mouse Anti-TBCB (AA 1-244) Recombinant Antibody (CBFYC-0400) (CBMAB-C0441-FY)

Datasheet

SDS

Target: TBCB

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYC-0400

Application*: WB, E

Mouse Anti-TBCB Recombinant Antibody (CBXC-2000) (CBMAB-C0071-CQ)

Datasheet

SDS

Target: TBCB

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXC-2000

Application*: WB, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)