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Mouse Anti-TBCB (AA 1-244) Recombinant Antibody (CBFYC-0400) (CBMAB-C0441-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0400
Antibody Isotype
IgG2b, k
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human TBCB (1-244aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG2b, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-244

Target

Full Name
TBCB Gene(Protein Coding) Tubulin Folding Cofactor B
Introduction
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.
Entrez Gene ID
1155
UniProt ID
Q99426
Alternative Names
CG22; CKAP1; CKAPI
Function
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649).
Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity).
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process nervous system developmentIEA:UniProtKB-KW
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.
PTM
Phosphorylation by PAK1 is required for normal function.
Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome.
(Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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