tac1

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene.

tachykinin, precursor 1

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

Biological Process antibacterial humoral responseIDA:UniProtKB
Biological Process antifungal humoral responseIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Biological Process cell-cell signalingTAS:ProtInc1 Publication
Biological Process cellular response to nerve growth factor stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionIEA:UniProtKB-KW
Biological Process defense response to Gram-negative bacteriumIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumIDA:UniProtKB
Biological Process detection of abiotic stimulusTAS:ProtInc1 Publication
Biological Process detection of temperature stimulus involved in sensory perception of painIDA:UniProtKB
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process innate immune responseIDA:UniProtKB
Biological Process inseminationTAS:ProtInc1 Publication
Biological Process killing of cells of another organismIDA:UniProtKB
Biological Process negative regulation of neuron deathIGI:ARUK-UCL
Biological Process negative regulation of systemic arterial blood pressureIDA:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB1 Publication
Biological Process positive regulation of flagellated sperm motilityIDA:UniProtKB
Biological Process positive regulation of neuron deathIGI:ARUK-UCL
Biological Process positive regulation of sensory perception of painIDA:UniProtKB
Biological Process regulation of sensory perception of painIDA:UniProtKB
Biological Process response to painIEA:Ensembl
Biological Process response to yeastIDA:UniProtKB
Biological Process sensory perception of painIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayIDA:UniProtKB1 Publication

Secreted

Substance P
The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817).
Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535).