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SUMO2

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Full Name
SUMO2
Function
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494).
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629).
Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).
Biological Process
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein sumoylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Nucleus, PML body
PTM
Polymeric chains can be formed through Lys-11 cross-linking. Polymeric SUMO2 chains undergo 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination by RNF4.
Cleavage of precursor form by SENP1 or SENP2 is necessary for function.
Monoubiquitinated N-terminally by UBE2W, which primes it for RNF4-dependent polyubiquitination by the UBE2V1-UBE2N heterodimer.

Anti-SUMO2 antibodies

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Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S2MT-1
Application*: IF, P
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: S23MT-1
Application*: IF, P, WB
Target: SUMO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXS-6167
Application*: IC, IF, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-2969
Application*: E, IH, WB
Target: SUMO2
Host: Mouse
Specificity: Human
Clone: CBXS-2652
Application*: E, IF, IH, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-2498
Application*: E, IF, WB
Target: SUMO2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1956
Application*: WB
Target: SUMO2
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1818
Application*: IP
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0861
Application*: SE, E, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-6102
Application*: E, F, IF, P, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4460
Application*: WB, E
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4077
Application*: IC, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5951
Application*: WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Hamster, Human, Mouse, Rat
Clone: CBXS-5916
Application*: WB, IF
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-3624
Application*: WB, E, IH, IF, P
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SUMO2/1199
Application*: F, P, IF, MC
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SPM621
Application*: P, IF, F
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM572
Application*: E, F, IF, IH, IP, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SM23/496
Application*: F, IF, IH, IP, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Common fruit fly, Mouse, Frog, Zebrafish
Clone: 8A2
Application*: IF, IP, WB
Target: SUMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H8
Application*: WB, E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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