STMN1

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

stathmin 1

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

AxonogenesisIEA:Ensembl
Establishment of skin barrierManual Assertion Based On ExperimentIMP:CAFA
Hepatocyte growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:MGI
Mitotic cytokinesisManual Assertion Based On ExperimentIMP:GO_Central
Mitotic spindle organizationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of guanyl-nucleotide exchange factor activityManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of microtubule polymerizationManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of Rho protein signal transductionManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIMP:CAFA
Neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular component movementIEA:Ensembl
Regulation of microtubule polymerization or depolymerizationManual Assertion Based On ExperimentIMP:CAFA
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Signal transduction1 PublicationNAS:ProtInc

Cytoplasm, cytoskeleton

Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity).
Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.