STAMBP

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq]

STAMBP

Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109).
Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065).
Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417).
Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516).
Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583).
Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583).
Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699).

Biological Process hippocampal neuron apoptotic processIEA:Ensembl
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:MGI
Biological Process negative regulation of hippocampal neuron apoptotic processIEA:Ensembl
Biological Process negative regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of Ras protein signal transductionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein deubiquitinationManual Assertion Based On ExperimentIMP:MGI
Biological Process protein K63-linked deubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc

Nucleus
Membrane
Cytoplasm
Early endosome

Microcephaly-capillary malformation syndrome (MICCAP):
A congenital disorder characterized by severe progressive microcephaly, early-onset refractory epilepsy, profound developmental delay, and multiple small capillary malformations spread diffusely on the body. Additional more variable features include dysmorphic facial features, distal limb abnormalities, and mild heart defects.

Phosphorylated after BMP type I receptor activation.
Ubiquitinated by SMURF2 in the presence of RNF11.