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SSBP1

SSBP is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]).[supplied by OMIM
Full Name
single-stranded DNA binding protein 1
Function
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA) (PubMed:21953457, PubMed:23290262, PubMed:31550240).
In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork (PubMed:21953457, PubMed:12975372, PubMed:26446790, PubMed:15167897, PubMed:31550240).
Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity (PubMed:26446790, PubMed:21953457, PubMed:31550240).
In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK (PubMed:12975372).
May also function in mtDNA repair (PubMed:23290262).
Biological Process
Biological Process DNA unwinding involved in DNA replicationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process mitochondrial DNA replicationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion morphogenesisIEA:Ensembl
Biological Process positive regulation of DNA helicase activityManual Assertion Based On ExperimentIDA:FlyBase
Biological Process positive regulation of helicase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of mitochondrial DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein homotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion
Mitochondrion matrix, mitochondrion nucleoid
Involvement in disease
Optic atrophy 13 with retinal and foveal abnormalities (OPA13):
An autosomal dominant disease characterized by visual impairment in association with bilateral optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. Many OPA13 patients also exhibit retinal pigmentary defects, attenuated retinal vasculature, macular dystrophy, and foveopathy. Some patients may develop additional systemic features, including sensorineural deafness and progressive nephropathy resulting in renal failure.

Anti-SSBP1 antibodies

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Target: SSBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0729
Application*: E, WB
Target: SSBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4997
Application*: WB, IP, E
Target: SSBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4C1
Application*: E, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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