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SRSF10

This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants.
Full Name
Serine And Arginine Rich Splicing Factor 10
Function
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198).
Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198).
Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198).
Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937).
Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937).
May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).
Biological Process
Biological Process cytosolic transportIEA:Ensembl
Biological Process mRNA splice site selectionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal tri-snRNP complex assembly1 PublicationNAS:UniProtKB
Cellular Location
Nucleus speckle
Cytoplasm
PTM
Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.

Anti-SRSF10 antibodies

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Target: SRSF10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A6
Application*: WB, E
Target: SRSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1035
Application*: WB, E
Target: SRSF10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3298
Application*: E, IF, IH, WB
Target: SRSF10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3824
Application*: E, IF, WB
Target: SRSF10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0719
Application*: E, IF, P, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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