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Mouse Anti-SRSF10 Recombinant Antibody (CBXS-3824) (CBMAB-S1094-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3824
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
0.39 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Serine And Arginine Rich Splicing Factor 10
Introduction
This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
10772
UniProt ID
O75494
Alternative Names
Serine And Arginine Rich Splicing Factor 10; Splicing Factor, Arginine/Serine-Rich 13A; FUS-Interacting Protein (Serine-Arginine Rich) 2; Protein Phosphatase 1, Regulatory Subunit 149; TLS-Associated Protein With Ser-Arg Repeats; Splicing Factor, Arginine/Serine-Rich 13; Serine/Arginine-Rich Splicing Factor 10; TLS-Associated Protein With SR Repeats; 40 KDa SR-Repressor Protein; Neural-Salient SR Protein; TLS-Associated SR Protein; SR Splicing Factor 10; Splicing Factor SRp38; SFRS13A; FUSIP1; FUSIP2; SRrp40;
Function
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198).
Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198).
Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198).
Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937).
Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937).
May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).
Biological Process
Biological Process cytosolic transportIEA:Ensembl
Biological Process mRNA splice site selectionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal tri-snRNP complex assembly1 PublicationNAS:UniProtKB
Cellular Location
Nucleus speckle
Cytoplasm
PTM
Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.
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For research use only. Not intended for any clinical use.

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